Qian Lab at UNC-Chapel Hill

If you are passionate about basic and translational research in the field of cardiovascular biology, and like to work in a creative and dynamic environment, please feel free to contact us!

 AddGene Plasmid Deposit: 

Newly deposited in year 2021:

Earlier deposited ones:

Read Dr Qian’s views and visions for the future of stem cell field:

Anniversary reflections: Inspiring discoveries and the future of the field. Cell Stem Cell 2022

Featured review article:

Direct cell reprogramming: approaches, mechanisms and progress. Nature Reviews Molecular Cell Biology 2021

Read Dr Qian’s philosophy on peer reviewing:

Evaluate with Care and Sensitivity. Cell 2019

Dr Qian’s Award assay:

Hope for the brokenhearted: cellular reprogramming improves cardiac function in a mouse model of myocardial infarction. Science 2016

 

Highlighted recent research articles:

Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition. Nature Cardiovascular Research 2023

Cross-lineage Potential of Ascl1 Uncovered by Comparing Diverse Reprogramming Regulatomes. Cell Stem Cell 2022

Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes. Cardiovascular Research 2021

Down-regulation of Beclin1 promotes direct cardiac reprogramming. Science Translational Medicine 2020

Singe cell transcriptomic analyses of cell fate transitions during human cardiac reprogramming. Cell Stem Cell 2019

Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte. Nature 2017

Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes. Cell Reports 2017

Bmi1 is a key epigenetic barrier to direct cardiac reprogramming. Cell Stem Cell 2016

Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes. Stem Cell Research 2016

In vivo cardiac reprogramming using an optimal single polycistronic construct. Cardiovascular Research 2015

Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming Circulation Research 2015

Early pioneering work on direct cardiac reprogramming:

In vivo reprogramming of murine cardiac fibroblasts into cardiomyocytes.  Nature 2012

Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nature Protocols 2013