If you are passionate about basic and translational research in the field of cardiovascular biology, and like to work in a creative and dynamic environment, please feel free to contact us!
We recently deposited the most frequently requested plasmids to AddGene. Have fun with them, and feel free to let us know if you have any question.
Recent review article:
Direct cell reprogramming: approaches, mechanisms and progress. Nature Reviews Molecular Cell Biology 2021
Selected research articles:
Down-regulation of Beclin1 promotes direct cardiac reprogramming. Science Translational Medicine 2020
Singe cell transcriptomic analyses of cell fate transitions during human cardiac reprogramming. Cell Stem Cell 2019
Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte. Nature 2017
Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes. Cell Reports 2017
Bmi1 is a key epigenetic barrier to direct cardiac reprogramming. Cell Stem Cell 2016
Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes. Stem Cell Research 2016
In vivo cardiac reprogramming using an optimal single polycistronic construct. Cardiovascular Research 2015
Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming Circulation Research 2015
Award assay:
Hope for the brokenhearted: cellular reprogramming improves cardiac function in a mouse model of myocardial infarction. Science 2016
Commentary preview in:
Advanced Technologies Lead iNto New Reprogramming Routes. Cell Stem Cell 2016
Read Dr Qian’s philosophy on peer reviewing:
Evaluate with Care and Sensitivity. (special Leading Edge “Voices” article) Cell 2019