Lab News

2022

August 13, 2022
Shea’s review article “The heart of cardiac reprogramming: the cardiac fibroblasts.” is accepted for publication  in JMCC.  Congratulations!
July 24, 2022
Haofei won the ACRE-APS Young Investigator Award (2nd prize) from AHA BCVS-ACS. Congratulations!
Yifang won the ACRE-APS Poster Award (2nd prize) from AHA BCVS-ACS. Congratulations!
June 9, 2022
Enjoy reading Dr Qian’s Voice article in Cell Stem Cell: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00205-3 This is in celebration of 15th anniversity for this flagship journal in the stem cell field. Dr.Qian serves on the editorial board.
June 1, 2022
Paige is awarded an NIH T-32 training grant from UNC Integrated Vascular Biology (IVB) Program. Congratulations!
May 9, 2022
Dr Qian receives UNC graduate school’s 2022 Faculty Award for Excellence in Doctoral Mentoring. Congratulations! Please read the news here: https://news.unchealthcare.org/2022/05/qian-receives-graduate-schools-2022-faculty-award-for-excellence-in-doctoral-mentoring/
April 21, 2022
Grace is awarded the CMSRP scholarship. Congratulations!
April 18, 2022
Ben successfully defended his thesis today. Now he is Dr.Keepers! Congratulations!

2021

November 2nd, 2021
Ben’s image “Eclipsed” was selected as one of the winners of 2021 Art in Science competition. Congratulations! Please read the news here: https://news.unchealthcare.org/2021/11/2021-art-in-science-competition-winners-announced/
September 4th, 2021
Haofei and Yuchen’s research article “Delineating Chromatin Accessibility Re-patterning at Single Cell Level during Early Stage of Direct Cardiac Reprogramming” is accepted for publication in The Journal of Molecular and Cellular Cardiology. Congratulations!
Aug 10, 2021
Hong, Ziqing and Yuchen’s research article “Functional coordination of non-myocytes plays a key role in in de novo heart regeneration” is accepted for publication in EMBO Reports . Congratulations!
July, 2021
Yifang’s review article “Direct cardiac reprogramming comes of age: recent advance and remaining challenges.” is accepted for publication  in Seminars in Cell and Developmental Biology.  Congratulations!
June 21, 2021
Shea is awarded an NIH T-32 training grant from UNC Integrated Vascular Biology (IVB) Program. Congratulations!
May 5, 2021
Haofei is awarded AHA postdoctoral fellowship for his project “Chromatin Accessibility Dynamic and AP-1′ s Role during Cardiac Reprogramming”. Congratulations!
April 5, 2021
Li Wang and Yuchen’s research article “Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes” is accepted for publication in Cardiovascular Research . Congratulations!
March 29, 2021
Greg is awarded AHA postdoctoral fellowship for his project “Elucidating the mechanisms controlling cardiac endothelial heterogeneity during aging”. Congratulations!
March 15, 2021
Yuchen’s research article “iSMNN: Batch Effect Correction for Single-cell RNA-seq data via Iterative Supervised Mutual Nearest Neighbor Refinement” is accepted for publication in Briefings in Bioinformatics . Congratulations!
February 22, 2021
Haofei and Yuchen’s review article “Direct cell reprogramming: approaches, mechanisms and progress” is now published in Nature Reviews Molecular Cell Biology. Congratulations!
February 12, 2021
The Well highlighted “For the love of heart research”: https://thewell.unc.edu/2021/02/12/for-the-love-of-heart-research
January 20, 2021
Dr.Qian received Emerging Investigator Award R35 with $6.5 million research funding from NHLBI. Congratulations! Reading the news here: https://news.unchealthcare.org/2021/01/qian-receives-emerging-investigator-award-with-6-5-million-research-fund-from-nih/

2020

November  11, 2020
Featured Story about Dr. Qian and Dr. Liu’s EIAs. Enjoy!

Their love of heart research brought them together, 20 years later they’re honored together for their accomplishments

October 26, 2020
Dr.Qian received Established Investigator Award from AHA. Congratulations!
September 17 , 2020
Ben is selected to be the winner for 2020 Trainee Choice Award at DPLM Annual Symposium. Congratulations!
September 16 , 2020
Li Wang’s research article “Downregulation of Beclin1 promotes direct cardiac reprogramming” is accepted for publication in Science Translational Medicine. Congratulations!
August 28 , 2020
Ben’s NIH F30 grant is funded (at his first submission!). This is a highly competitive 4-year fellowship for MD/PhD student. Congratulations!
April 9 , 2020
Greg’s review article “Reprogramming of Non-myocytes into Cardiomyocyte-like Cells: Challenges and Opportunities” is accepted for publication  in Current Cardiology Reports.  Congratulations!
March 16 , 2020
Tiffany is offered the position as Assistant Science Editor, Creative Services Division at The Scientist. Congratulations! Wish all the best luck to Tiffany at this exciting new position!
February 28 , 2020
Haley successfully defended her thesis today, and now becomes Dr.Chi! Congratulations!
January 20 , 2020
Li Wang’s research article “Isoform Specific Effects of Mef2C during Direct Cardiac Reprogramming” is accepted for publication in Cells. Congratulations!

2019

December 13, 2019
Tiffany and Yang’s paper “An Optimized Protocol for Human Direct Cardiac Reprogramming” is accepted for publication in STAR Protocols. Congratulations!
December 11, 2019
Dr Qian is awarded 2019-2020 Yang Family Biomedical Scholar. Congratulations! Read UNC news here: http://news.unchealthcare.org/news/2019/december/unc-school-of-medicine-celebrates-2019-20-yang-family-biomedical-scholars
October 10, 2019
Dr. Qian is featured at “Endeavor”. Enjoy reading the full story ! Now highlighted at UNC university website: https://www.unc.edu/discover/mending-broken-hearts/
September 18, 2019
Dr. Qian was nominated as one of their best reviewers by editors from Cell Press. She shares her experience and philosophies on peer reviewing at this issue of Cell.

UNC news: https://www.med.unc.edu/compmed/2019/09/prestigious-journal-names-li-qian-as-top-reviewer/

September 12, 2019

 Tiffany wins 2019 Excellence in Research Presentation Award at Dept of Pathology and Laboratory Medicine Annual Symposium. Congratulations!

August 22, 2019
Dr.Qian receives the prestigious 2019 Hettleman Prize for Artistic and Scholarly Achievement. Congratulations!
2019 Hettleman Prizes Awarded to Promising Early-Career Faculty

Wang, Qian honored with 2019 Hettleman Prizes
June 20, 2019
News about our CSC paper (online today):
Scientists Make Single-Cell Map to Convert Scar Tissue into Healthy Heart Cells;
McAllister Team From Li Qian’s Lab Publish New Research in Cell Stem Cell.
May 22, 2019
       Yang and Ziqing’s paper “Single Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming” is accepted for publication in Cell Stem Cell. Congratulations!
May 15, 2019
       Peisen’s research article “Atorvastatin Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction via Up-regulating Long Non-coding RNA H19” is accepted for published in Cardiovascular Research. Congratulations!
April 13-14, 2019
       Dr.Qian is invited to talk with Adam on YOUR HEALTH radio show. You can catch the episode on 97.9 FM The Hill or KKAG Retro Radio 88.3FM:

March 21, 2019
      Ben’s review article “What’s in a Cardiomyocyte – and How Do We Make One through Reprogramming?” is accepted for published in BBA-Molecular Cell Research. Congratulations!
February 1, 2019
       Dr.Qian has been selected as a winner of Triangle Business Journal‘s 2019 Health Care Heroes Awards as a Rising Star. Dr.Qian receives this Award based on her impactful research on mechanisms of regeneration and repair of injured hearts, and will be honored at an event at the Umstead Hotel in Cary on March 14lations!

Read news here at Vital Sign: http://news.unchealthcare.org/news/2019/january/tbj-selects-seven-health-care-heroes-from-unc-medical-center-school-of-medicine
January 3, 2019
        Yang formally started her position as Assistant Professor at UAB. Congratulations!
January 2, 2019
        Dr.Qian is officially on the Advisory Editorial Board of Development. She very much looks forward to this new role in helping the developmental biology and stem cell community!

2018

November 27, 2018
        Ben Keepers is awarded an NIH T-32 training grant from UNC Integrated Vascular Biology (IVB) Program. Congratulations!

 

November 27, 2018
        Our collaborative work “Lin28a regulates pathological cardiac hypertrophic growth through Pck2-mediated enhancement of anabolic synthesis” with Liu Lab is accepted for publication in Circulation. Congratulations!

 

October 1, 2018
          Dr.Qian is appointed Associate Director of McAllister Heart Institute. Read UNC news here: http://news.unchealthcare.org/news/2018/november/qian-appointed-associate-director-of-mcallister-heart-institute

 

September 24, 2018
          Yang Zhou received Postdoctoral Award for Research Excellence for the 2018-2019 academic year. This is a prestigious honor for postdoc fellows at UNC, selected among candidates across all schools/disciplines. Congratulations!
(Terry Magnuson, Vice Chancellor for Research (left) and Yang Zhou (right) at the award ceremony)
July 18, 2018
          Dr.Qian received 2018 Transformational Project Award from American Heart Association. Congratulations!
Read news at SOM Vital Signs here: http://news.unchealthcare.org/som-vital-signs/2018/aug-2/2018-transformational-project-award-from-american-heart-association-for-li-qian-phd?utm_source=vs-email&utm_medium=email&utm_campaign=31
May 24, 2018
          Dr.Qian’s promotion to Associate Professor with tenure is approved. Congratulations!
 May 9, 2018
Li Wang received prestigious Career Development Award from AHA. Congratulations!
Read about from SOM Vital Signs news: http://news.unchealthcare.org/som-vital-signs/2018/june-14/li-wang-receives-career-development-award-from-american-heart-association
April 20, 2018
           Haley’s AHA Predoctoral Fellowship is funded at her first submission. She received a historical score: 1. 22 Priority Score and 0.19% Percentile Rank (funding line is 29.28%). Congratulations!
March 1, 2018
Dr.Qian passionately discussed with UNC MD-PhD Women in Science at the Microaggressions and Harassment Panel. It was a great success.

February 27, 2018
Haley received 2018 Pryzwansky Young Investigator Award from our graduate program (only one per year) in recognition of her outstanding accomplishments as a young scientist. Congratulations!
January 30, 2018
Ziqing and Li gave an excellent Webinar hosted by DahShu about our recent single cell work: https://www.eventbrite.com/e/single-cell-transcriptomics-reconstructs-fate-conversion-from-fibroblast-to-cardiomyocyte-tickets-41939807092

January 11, 2018
Our collaborative work “Diabetes exacerbates myocardial ischemia reperfusion injury by downregulation of microRNA and upregulation of O-GlcNAcylation” with Xiang Lab, Hwa Lab is accepted for publication in JACC Basic Transl Sci. Congratulations!”
January 4, 2018
Our lab’s research in 2017 was one of the UNC SOM “favorite stories in 2017”. Read the news here: https://news.unchealthcare.org/news/2017/december/a-look-back-at-our-favorite-stories-of-2017?utm_source=vs-email&utm_medium=email&utm_campaign=1. Congratulations!

2017

December 4, 2017
Yang’s research article “A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming” is accepted for publication in Stem Cells International. Congratulations!
November 27, 2017
Our paper is among the Top10 Nature papers this month. Congratulations for this recognition!
November 21, 2017
Invited by The Node from journal Development, Ziqing has shared a behind-the-scenes story about our single cell omics project. http://thenode.biologists.com/looking-back-adventure-exploring-cell-fate-conversion-single-cell-rna-seq/research/. Enjoy!

October 25, 2017
News story about our Nature paper: How to Turn Damaged Heart Tissue Back into Healthy Heart Muscle: New Details Emerge. Enjoy reading!
NIH/NHLBI highlights our study: https://www.nhlbi.nih.gov/news/news-mentions
October 16, 2017
Ziqing is promoted to a research track faculty position and starts her new position today. Big congrats to her and wish her the best!
September 26, 2017
News story about Yang’s paper: Post Heart Attack: How can scar tissue be turned back into healthy heart muscle?  Enjoy reading!
September 22, 2017
Ziqing and Li W’s research article “Single Cell Transcriptomics Reconstructs Fate Conversion from Fibroblast to Cardiomyocyte” is accepted for publication in Nature. Congratulations!
September 19, 2017
Dr.Qian is honored 2017 Outstanding Mentor Award. Congratulations!
UNC News: Qian, Meshnick earn UNC mentorship awards
August 31, 2017
Yang Zhou’s research article “Comparative gene expression analyses reveal distinct molecular signatures between differentially reprogrammed cardiomyocytes” is accepted for publication in Cell Reports. Congratulations!
August 1, 2017
Li Wang’s book chapter “In vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration” as part of the book “In Vivo Reprogramming in Regenerative Medicine” is scheduled to be published by Springer this October. Congratulations!
June 16, 2017
J. Blake Wall is accepted into the Class of 2021 at New York Medical College and will start medical school this fall. Congratulations! Wish him the best!
May 5, 2017
Olivia Chen graduated from medical school! She will start her internship at UC and then residency at U of Mich. Congratulations and wish her the best!
May 1, 2017
Sahar Alimohamadi is accepted by the Medical College of Georgia and will start medical school this fall. Congratulations! Wish her the best!
April 24, 2017
Dr.Qian’s interview is published in this issue of Research Features Magazine. Enjoy reading the story “Repairing a broken heart“!
April 12, 2017
Ziqing Liu’s research article “Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector” is accepted for publication in Scientific Reports. Congratulations!
March 18, 2017
Haley Vaseghi’s review paper “Molecular barriers to direct cardiac reprogramming” is accepted for publication in Protein&Cell. Congratulations!

2016

November 17, 2016
Featured story about Dr.Qian “Following the ‘Tinman‘”.
October 17, 2016
Dr. Qian was selected as the winner of 2016 Jefferson Pilot Award in Academic Medicine. Congratulations!
October 14, 2016
Li Wang won the poster award at the 2016 DPLM Annual Research Symposium. Congratulations!
Dr. Qian won the CMI Functional Tissue Engineering Seed Grant. Congratulations!
September 1, 2016
Yang Zhou’s commentary preview “Advanced Technologies Lead iNto New Reprogramming Routes” is published in Cell Stem Cell. Congratulations!
July 8, 2016
Dr. Qian is named as “Hometown Hero” by Chapelboro.com:    http://chapelboro.com/lifestyle/hometown-heroes/li-qian-hometown-hero
Featured news story “A ‘crazy idea’ to cure heart disease” http://chapelboro.com/featured/a-crazy-idea-to-cure-heart-disease
June 24, 2016
Science/AAAS published a News Story about Dr. Qian. Read the story here: http://www.aaas.org/news/science-winner-aaas-award-stem-cells-and-regenerative-medicine-demonstrates-how-heart-cells-can
June 17, 2016
The breaking news “The re-programmer: Qian receives global award for stem cell research” is on the front page of UNC SOM website. Read the story here: http://news.unchealthcare.org/news/2016/june/the-re-programmer-qian-receives-global-award-for-stem-cell-research
Dr. Qian’s assay “Hope for the brokenhearted: cellular reprogramming improves cardiac function in a mouse model of myocardial infarction” is published in Science today. Enjoy reading it: http://science.sciencemag.org/content/352/6292/1400
May 17, 2016
Haley Vaseghi’s paper “Generation of an inducible fibroblast cell line for studying direct cardiac reprogramming” is accepted for publication in Genesis. Congratulations!
May 13, 2016
Dr. Qian was selected to be the winner of the inaugural 2016 Boyalife Prize in Stem Cells and Regenerative Medicine. Congratulations!
April 22, 2016
Yingao Zhang is awarded the fellowship from Carolina Medical Student Research Program (CMSRP). Congratulations!
March 30, 2016
Dr. Qian is honored 2016 URC Publication Award. Congratulations!
March 16, 2016
Hong Ma’s paper “Fat for Fostering: Regenerating Injured Heart Using Local Adipose Tissue.” is accepted for publication in EBioMedicine (the new journal launched by the prestigious Cell and The Lancet). Congratulations!
March 7, 2016:
Dr. Qian is invited to give a keynote talk on “Mending a broken heart: from developmental biology to regenerative medicine” at the 7th Annual Translational Medicine Symposium on April 8th.
March 3, 2016:
UNC news “Broken heart breakthrough” reporting our exciting discoveries to public!
March 2, 2016:
Haley Vaseghi gave an excellent talk on “Generation of an Inducible Fibroblast Cell Line for Direct Cardiac Reprogramming” and won the 1st place for travel awards at 2016 RTP-DMDG Winter Symposium. Congratulations!
February 25, 2016:
Haley Vaseghi (abstract “Generation of an Inducible Fibroblast Cell Line for Direct Cardiac Reprogramming”) has been selected as the one of two finalists for travel awards, and invited for an oral presentation at the upcoming 2016 RTP-DMDG Winter Symposium “Next Gen Culture: The Future of Cell and Tissue Models in Research, Drug Development and Therapy”. Congratulations!
February 24, 2016:
Ziqing Liu’s paper, “Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes” is accepted for publication in Stem Cell Research. Congratulations!
February 12, 2016:
Yang Zhou’s paper, “Bmi1 is a key epigenetic barrier to direct cardiac reprogramming.” is accepted for publication in Cell Stem Cell. Congratulations!
January, 2016:
Hong Ma and Li Wang’s book chapter, “Direct cardiac reprogramming as a novel therapeutic strategy for treatment of myocardial infarction” will be published in Methods in Molecular Biology, by Springer

2015

September 16, 2015:
Hong Ma’s paper, “In Vivo Cardiac Reprogramming Using an Optimal Single Polycistronic Construct” is accepted for publication in Cardiovascular Research (Editor’s Choice).
June 27, 2015:
Haley Vaseghi is awarded an NIH T-32 training grant from UNC Integrated Vascular Biology (IVB) Program.
June 24, 2015:
Haley Vaseghi is named as the 2015 Sykes Scholar by Department of Pathology and Laboratory Medicine.
April 29, 2015:
Olivia Chen’s paper, “Direct Cardiac Reprogramming: Advances in Cardiac Regeneration” is accepted for publication in Biomedical Research International.
April 22, 2015:
Li Wang’s paper, “‘Improved generation of induced cardiomyocytes using a polycistronic construct expressing optimal ratio of Gata4, Mef2c and Tbx5” is accepted for publication in the Journal of Visualized Experiments (JoVE).
March 2, 2015:
Ziqing Liu’s abstract, “Impact of Gata4, Mef2c and Tbx5 Stoichiometry on Epigenetic Status of Direct Cardiac Reprogramming” is selected for an oral presentation at 2015 IVB/MHI Annual Symposium.
February 10, 2015:
Qiang Zhu’s paper, “Induced cardiomyocytes from non-myocytes for cardiac repair” is accepted for publication in Chinese Journal of Hypertension.

2014

November 21, 2014:
Li Wang and Ziqing Liu’s paper, “Stoichiometry of Gata4, Mef2c and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming” is accepted for publication in Circulation Research.
November, 2014:
Dr. Qian is elected to the UNC Core Facility Advocacy Committee (CFAC).
Dr. Qian is elected to the Pathology Graduate Program Executive Committee.
July 19, 2014:
Chuner Guo’s paper, “Cardiomyocyte-specific role of miR-24 in promoting cell survival” is accepted for publication in the Journal of Cell and Molecular Medicine.
July 8, 2014:
Ashley Fuller’s paper, “MiRiad roles for microRNAs in cardiac development and regeneration” is accepted for publication in Cells.
June 19, 2014:
Ashley Fuller is awarded an NIH T-32 training grant from the Integrated Vascular Biology (IVB) Program.
May 1, 2014:
Chuner Guo is admitted to the MD/PhD program at Washington University, St Louis, and moves onto the next exciting phase of her career.
Olivia Chen is awarded a fellowship from the Carolina Medical Student Research Program.
March 17, 2014:
Dr. Qian is elected to the School of Medicine Assistant Professor Advisory Committee (APAC)
February 5, 2014:
Drs. Li Qian and Jiandong Liu are awarded the MHI/Cardiology 20K Grant.

2013

December 16, 2013:
Dr. Li Qian is awarded the 2014 Junior Faculty Development Award from the UNC Provost Office.
November 26, 2013:
Li Wang’s paper, “miR-24 regulates intrinsic apoptosis pathway in mouse cardiomyocytes” is accepted for publication in Plos One.
August 8, 2013:
Dr. Li Qian is honored as the 2013 Ellison New Scholar in Aging by the Ellison Medical Foundation.
News link: http://news.unchealthcare.org/news/2013/september/li-qian-receives-new-scholar-in-aging-award-from-ellison-medical-foundation
June 25, 2013:
Kim Bird’s paper, “Cellular reprogramming for cardiovascular disease” is accepted for publication in the Journal of Tissue Science & Engineering.
June 5, 2013:
Dr. Li Qian is awarded the American Heart Association Scientist Development Grant (2013-2017)
May 30, 2013:
Dr. Li Qian’s Nature Protocols paper, “Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro” is published online today, and is highlighted as a feature protocol on the Nature website.
May 7, 2013:
Link to UNC news about Dr. Li Qian: http://news.unchealthcare.org/heartandvascular/news/2013/mending-a-broken-heart
April 23, 2013:
Kim Bird is awarded a Sabin Travel Award
March 29, 2013:
Kim Bird is awarded an NSF Pre-doctoral Fellowship
January 11, 2013:
Chuner Guo’s and Kishan Patel’s paper, “Direct somatic cell reprogramming: treatment of cardiac diseases,” is accepted for publication in Current Gene Therapy.

2012

December 17, 2012:
Dr. Li Qian’s research is cited as one of the top 10 advances in heart disease and strong research by the American Heart Association.

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